The reason for this study is to determine the long-term efficacy and safety of the study drug
mirikizumab in participants with Crohn's disease.

A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease

Casper

Care Access - Casper

Mirikizumab

A Phase 3, Multicenter, Open-Label, Long-Term Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients With Crohn's Disease

A retrospective review of body composition changes in patients who participate in a 9-week
non-invasive intensive health care provider supervised weight loss program as an overall
cohort and in sub-cohorts of interest.

Evaluation of Body Composition Improvement With Visceral Adiposity-Focused Anti-Obesity Telehealth Program

Cheyenne

20Lighter Telehealth Program

20Lighter Program

This phase II trial studies how well vemurafenib and cobimetinib work in treating patients
with BRAF V600E mutation positive craniopharyngioma. Vemurafenib and cobimetinib may stop the
growth of tumor cells by blocking some of the enzymes needed for cell growth.

Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma

Sheridan

Welch Cancer Center

Vemurafenib

Cobimetinib

Laboratory Biomarker Analysis

Quality-of-Life Assessment

Phase II Trial of BRAF/MEK Inhibitors in Papillary Craniopharyngiomas

This trial studies the genetic and behavioral factors that may contribute to the development
of specific cancers and how these factors may affect the outcome of the disease in patients
with a history of cancer and their relatives.

Molecular Genetics Studies of Cancer Patients and Their Relatives

Cheyenne Regional Medical Center-West

Biospecimen Collection

Questionnaire Administration

A randomized trial to determine whether simultaneous treatment with spectacles and patching
has an equivalent VA outcome compared with sequential treatment, first with spectacles alone
followed by patching (if needed), for previously untreated amblyopia in children 3 to <13
years of age.

A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

Laramie

Snowy Range Vision Center

Patching

Glasses

A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles Plus Patching for Amblyopia in Children 3 to <13 Years Old

Nearly one in five children in the United States has a mental health problem that interferes
with daily functioning and requires intervention, and yet less than 50% of children who need
mental health care receive any services. Families and especially from low-income and
ethnically diverse backgrounds, experience a range of barriers to engaging in services for
their children including: lack of recognition of problems and knowledge of available
treatments, connecting to services, trust in providers, stigma; low income and ethnically
diverse populations are especially affected by these barriers. In this work, the
investigators propose to carry out initial testing of a research- and theory-based model of
Parent Peer Navigation services to help engage families with children with significant but
pre-clinical problems in mental health services in order to prevent future poorer outcomes
for children, who otherwise may never receive services, or only receive services when their
mental health issues become severely debilitating for themselves and their family.

Navigation and Parent Peer Support to Promote Access

Uplift Wyoming

Parent Peer Navigation

Navigation and Parent Peer Support to Promote Access and Retention of Children in Mental Health Services

This is a randomized, double-blind, two-treatment, single-period, parallel design, multiple
dose at multiple clinical trial sites designed to demonstrate bioequivalence with clinical
endpoint in subjects with chronic open-angle glaucoma or ocular hypertension in both eyes.
Test Product - Bimatoprost ophthalmic solution, 0.01% of Amneal EU, Limited Reference Product
- LUMIGAN® (bimatoprost ophthalmic solution) 0.01% of Allergan, Inc.

Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.

Cheyenne Eye Clinic & Surgery Center

Test - Bimatoprost 0.01% Ophthalmic Solution

Reference - LUMIGAN® (Bimatoprost 0.01% Ophthalmic Solution)

A Randomized, Double-blind, Multiple Dose, Parallel-group, Two-arm, Multicenter, Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® (Bimatoprost Ophthalmic Solution) 0.01% in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes

This phase II trial compares two treatment combinations: gemcitabine hydrochloride and
nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older
patients with pancreatic cancer that has spread to other places in the body (metastatic).
Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, fluorouracil,
leucovorin calcium, and liposomal irinotecan, work in different ways to stop the growth of
tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them
from spreading. This study may help doctors find out which treatment combination is better at
prolonging life in older patients with metastatic pancreatic cancer.

Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread

Fluorouracil

Gemcitabine

Gemcitabine Hydrochloride

Leucovorin

Leucovorin Calcium

Liposomal Irinotecan

Nab-paclitaxel

A Randomized Phase II Study of Gemcitabine and Nab-Paclitaxel Compared With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan in Older Patients With Treatment Naïve Metastatic Pancreatic Cancer (GIANT)

Half or nearly half of college students with prescriptions divert their stimulant medication,
and a similarly high percentage misuse their medication or use someone else's prescription.
Diversion may lead students to go without needed medication to mitigate their symptoms,
increasing their risk for unintentional injuries and substance use. Further, diversion
perpetuates the non-medical use of prescription stimulants (NMUPS), which has become
increasingly common among college students. Diversion also perpetuates medical misuse of
stimulants among students with prescriptions, which is associated with poorer
attention-deficit/hyperactivity disorder (AD/HD) symptom management and may increase the risk
for addictive disorders. There are no evidence-based interventions targeting diversion of
stimulants in college students. Being approached for one's medication is a key risk factor
for diversion, as is medication non-adherence and believing NMUPS and diversion are more
prevalent than they are. Accordingly, in this multi-site study, the investigators will
conduct a randomized, controlled trial of 300 college-attending adults with current stimulant
prescriptions to examine the preliminary efficacy and feasibility of a single-session,
computer-based simulation intervention (with two booster sessions) to prevent prescription
stimulant diversion and medication misuse and compare it to a placebo condition. The
intervention, which is grounded in social learning theory and the theory of planned behavior
uniquely engages students in interactive discussions with virtual humans to (a) learn about
the actual prevalence of NMUPS and diversion and their related risks, (b) practice using
refusal strategies when approached for their medication in high-risk situations, and (c)
understand how to effectively communicate with prescribers and avoid medication misuse. The
primary aims are to determine if the intervention reduces diversion, intentions to divert,
and medication misuse, and to assess user satisfaction with the intervention. The secondary
aims are to examine change in potential mechanisms of action targeted in the intervention,
such as self-efficacy to resist diversion, knowledge about diversion and NMUPS, use of
behavioral strategies to resist requests for one's medication, and prescriber communication.
If effective, the intervention could be readily and widely disseminated to college counseling
centers, psychiatrists, pediatricians, and other prescribers.

Preventing Prescription Stimulant Diversion and Medication Misuse Via a Web-Based Simulation Intervention

University of Wyoming

Web-based placebo presentation

Web-based simulation active intervention

The overall purpose of this study is to quantify the effect and retention of one-week
training of falling techniques on landing biomechanics associated with anterior cruciate
ligament (ACL) loading compared to soft-landing techniques in young recreational athletes.
The secondary purpose is to assess the safety of the training program.
Aim 1: To quantify the effect of one-week training of falling techniques on landing
biomechanics during forward, lateral, vertical, and diagonal landings compared to
soft-landing techniques. We hypothesize that falling techniques will result in increased knee
flexion angles and decreased landing forces, knee abduction and internal rotation angles, and
knee moments for all landing directions compared to soft-landing techniques immediately after
the training.
Aim 2: To assess the retention effects of the falling techniques on landing biomechanics
compared to soft landings. We hypothesize that the effects of falling techniques on ACL
loading variables will be more highly retained compared to soft-landing techniques two weeks
after the training.
Aim 3: To identify the safety of the training program. We hypothesize that participants can
complete the training without suffering minor, moderate, or major injuries, while occasional
minor bruises might be observed.

Training of Falling Techniques on Landing Mechanics

Falling Training

One-week Training of Falling Techniques on Landing Biomechanics Associated With Anterior Cruciate Ligament Loading

Wyoming