Right now, doctors at select centers in the U.S. are accepting participants for a new clinical research study to evaluate how AMX0035 may be able to help slow decline due to ALS.
AMX0035 is an oral combination of two small molecules, sodium phenylbutyrate (PB) and tauroursodeoxycholic acid (TUDCA). Each compound has shown efficacy in several cellular and animal models of ALS.
Small clinical trials have supported the potential for safety and efficacy of these compounds; however, this larger trial is needed to confirm these findings.
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ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Eventually, people with ALS lose the ability to initiate and control muscle movement, which leads to total paralysis and death, usually within two to five years of diagnosis.
Dr. Sabrina Paganoni from Massachusetts General Hospital discusses CENTAUR, a phase 2 trial for people with ALS.
The staff at the nearest clinical trial site will help determine if your loved one meets the criteria for the study. This study is looking for individuals who are:
Participating in the study will last for approximately 30-34 weeks, and includes:
- 24 weeks of treatment
- Additional screening assessments, which will take up to 6 weeks
- 4 weeks of safety follow up after the treatment is completed
The CENTAUR-OLE study provides patients with the option of continuing treatment once they have completed the 24-week study period.
The trial will evaluate AMX0035’s ability to have an impact on daily functioning, muscle strength, and respiratory function as well as its ability to alter biological markers of ALS.
For more information, fill out the form, contact (617-724-7210), or email Emily Engel at [email protected]