Study of Open Label Losartan in COVID-19
Clara Health

Study of Open Label Losartan in COVID-19

Sponsored by University of Kansas Medical Center


This is an open label, phase 1 clinical trial to evaluate the safety of losartan in respiratory failure due to COVID-19.

About 
COVID-19

Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first identified during an investigation into an outbreak in Wuhan, China.

How is this study designed?

Study Type: Interventional (Clinical Trial) Estimated Enrollment: 50 participants Primary Purpose: Treatment Actual Study Start Date: March 25, 2020 Estimated Study Completion Date: October 2020

Who is this study for?

Inclusion Criteria*:

  • Age >18 years admitted to the University of Kansas Health System.
  • Confirmation of infection with SARS-CoV-2 by PCR testing.
  • Hypoxic respiratory failure
  • Requiring mechanical ventilation or oxygen, an oxygen saturation (SpO2) ≤94% or a PaO2/FiO2 (P/F) ratio <300 or tachypnea (respiratory rate ≥24 breaths/min).
  • Other concomitant medications such as antivirals and hydroxychloroquine are allowed.

Exclusion Criteria*:

  • Pregnancy.
  • Respiratory failure due to a process other than COVID-19.

* Additional criteria apply. Please speak with the study team for further information.

What should I expect?

  • Briefly, 50 patients with COVID-19 and respiratory failure who meet criteria and agree to participation in the study will be placed on losartan 25 mg daily on study day 0.
  • If parameters are met the dose of losartan will be increased to 50 mg on study day 3.
  • Participants will continue losartan until they experience resolution of respiratory failure (normal oxygen levels on room air), are discharged from the hospital, meet stoppage criteria (detailed below) or complete 14 days of therapy.
Inpatient trial

Have questions or need help?

For general questions about COVID-19 clinical trials, please email [email protected] For study specific inquiries, submit the interest form and you'll be connected to the team.